Figure 3

Changes in structural connectivity after CPSP development overlaid on the fractional anisotropy image of the DTI-based atlas. For tractography, the lesion side of the entire thalamus was selected as the seed. The axial (left), coronal (upper right), and sagittal (lower right) slices are shown. The xyz coordinate is defined at the anterior commissure. The blue areas indicate that the structural connectivity was decreased after the lesion (uncorrected p < 0.001 and cluster-size adjusted p-FDR < 0.05). The red, yellow and green areas are S1, S2 and VPL, respectively, marked from the template atlas. A anterior, CPSP central poststroke pain, FDR false discovery rate, L left, S1 primary somatosensory cortex, S2 secondary somatosensory cortex, VPL ventral posterolateral nucleus in the thalamus.