Table 3 Uni- and multi-variate analysis of factors associated with late recurrence (n = 75).

From: Liver stiffness and insulin resistance in predicting recurrence for early stage hepatoma patients after curative resection

Model 1

Associated factor

Comparison

Univariate

HR (95% CI)

p value

Multivariate*

HR (95% CI)

p value

Hepatitis etiology

NBC

Reference

   

B

1.82 (0.23–14.25)

0.568

C

2.64 (0.34–20.67)

0.355

BC

6.55 (0.40–107.64)

0.188

Fibrosis stage

0/1/2

Reference

   

3/4

1.88 (0.74–4.81)

0.187

LS (kPa)

 ≤ 8.5

Reference

 

Reference

 

 > 8.5

3.18 (1.24–8.14)

0.016

2.72 (1.05–7.07)

0.039

ICG (%)

 

1.04 (0.99–1.09)

0.152

  

ALP (U/L)

 

1.03 (1.01–1.04)

0.008

  

HOMA-IR

 

1.25 (1.08–1.44)

0.003

1.24 (1.07–1.44)

0.003

Model 2

Hepatitis etiology

NBC

Reference

0.568

  

B

1.82 (0.23–14.25)

 

C

2.64 (0.34–20.67)

0.355

BC

6.55 (0.40–107.64)

0.188

Fibrosis stage

0/1/2

Reference

0.187

  

3/4

1.88 (0.74–4.81)

 

ICG (%)

 

1.04 (0.99–1.09)

0.152

  

ALP (U/L)

 

1.03 (1.01–1.04)

0.008

  

HOMA-IR and LS

HOMA ≤ 2.3 and LS ≤ 8.5

Reference

 

Reference

 

HOMA > 2.3 and LS ≤ 8.5

1.11 (0.13–9.57)

0.921

1.09 (0.13–9.39)

0.935

HOMA ≤ 2.3 and LS > 8.5

2.42 (0.83–7.10)

0.106

2.15 (0.72–6.41)

0.171

HOMA > 2.3 and LS > 8.5

6.50 (1.97–21.52)

0.002

6.47(1.95–21.42)

0.002

  1. B hepatitis B virus, C hepatitis C virus, NBNC non-hepatitis B virus and non-hepatitis C virus, LS liver stiffness, ICG indocyanine green, ALP alkaline phosphatase, HOMA-IR homeostatic model assessment for insulin resistance, *all characteristics in Table 1 were included in the univariable analysis and those with p values < 0.2 were entered into stepwise multivariable analysis.
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