Figure 6

Caveolin-1 is necessary for renal and vascular inflammation in noradrenaline-induced hypertension. Minipumps containing saline (grey bars) or noradrenaline (NA; 3.8 µg/kg/min; black bars) were inserted into 8–10 week-old caveolin-1 knockout (Cav1^−/−) mice and C57Bl/6 wild-type controls (WT) for a period of 2 weeks. (A) Systolic blood pressure was measured via tail-cuff plethysmography (n = 6–10). (B-E) Renal gene expression of Adgre1, Cd68, Icam1, and Il6 was determined via real-time PCR (n = 4–6). Aortae were excised from saline- or NA-treated Cav1^−/− and WT mice and the number of adhered leukocytes quantified (F; n = 6–8). Aortic gene expression for Ccl2, Icam1, and Il6 was also determined via real-time PCR (G-I; n = 5–7). All results are expressed as mean ± SEM. Data.