Figure 3
From: Adipose most abundant 2 protein is a predictive marker for cisplatin sensitivity in cancers
Microarray and bioinformatic analyses. Microarray analyses were performed to compare the levels of gene expression in mock-transfected HLE and APM2-transfected HLE. A total of 6169 genes with more than two-fold differences in the expression were clustered hierarchically according to level of gene expression. (a) Downregulated (> 2 folds) and (b) upregulated (> 2 folds) genes. The color represents the expression level of the gene: green represents low changes of expression, whereas red represents high changes of expression. The expression levels are continuously mapped on the color scale (a, 2–247.1-fold change; b, 2–69.2-fold change). (c, d) Ten groups were assessed with related gene expressions using gene ontology term analyses. (e) Gene expression network analysis based on the microarray assays using the in vitro APM2 overexpressing cell lines (HLE). Inset focuses on the significantly related genes. APM2, adipose most abundant 2.
