Figure 5
From: Machine learning to determine optimal conditions for controlling the size of elastin-based particles
(a) A weak relationship was seen between Rh and Tt with an R2 of 0.3. (b) K-means cluster analysis was used to elucidate the primary driver of the relationship between Rh and Tt. The three groups indicated by K-means cluster analysis to be important for determining Rh versus Tt are based on the concentration of salt. (c) Separating the Rh versus Tt graph by polymer type shows that increasing the molecular weight of PEI attached to ELP decreased the Rh and Tt simultaneously. Graphs for (d) ELP, (e) ELP/ELP-PEI800, and (f) ELP/ELP-PEI10K demonstrate that increasing polymer concentration decreases Tt, but has a small influence on Rh. (g) ELP exhibits minimal effects from a change in pH. Coupling ELP to PEI imposes a pH sensitivity that allows for a control over Rh for (h) ELP/ELP-PEI800 and (i) ELP/ELP-PEI10K.
