Figure 5 | Scientific Reports

Figure 5

From: Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

Figure 5

Effect of type 2 diabetes progression on AGEs levels and AGEs receptor expression. (a) Average relative levels of AGEs, and the loading protein Calnexin, on aorta and PA of control animals (n = 3–4) and animals submitted to HF (n = 3–4) or HFHSu (n = 6–8) diets. (b) Average relative expression of RAGE (42 kDa) and the loading protein used—Calnexin (90 kDa) or GAPDH (37 kDa)—in aorta and PA of control animals (n = 4–5) and animals submitted to HF (n = 4–5) and HFHSu (n = 4–5) diets. Representative western blots for each protein studied are depicted above the respective graphs. For complete membrane image see Supplementary data. Values are presented as scatter plots ± SD; One-way ANOVA with Dunnet’s comparison test. *p < 0.05 and **p < 0.01 versus control animals; #p < 0.05 comparing the groups submitted to the hypercaloric diets.

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