Figure 8 | Scientific Reports

Figure 8

From: Type 2 diabetes progression differently affects endothelial function and vascular contractility in the aorta and the pulmonary artery

Figure 8

Effect of prediabetes and early phase type 2 diabetes on vascular mineralization. Histological analysis of the arteries stained with Hematoxylin and Eosin staining. No mineralization was observed on the aorta of the control, HF and HFHSu animals (a, top panel; left to right images, respectively). Mineralization was observed in the PA of various control and HF animals and in the PA of all the HFHSu animals (a, bottom panel; left to right images, respectively). (b) Vascular mineralization levels in PA of control (n = 7), HF (n = 4) and HFHSu (n = 8) animals. (c) Masson's trichrome staining for collagen evaluation. No alterations were observed on collagen in the aorta of the control, HF and HFHSu animals (c, top panel; left to right images, respectively) nor in the PA of the control, HF and HFHSu animals (c, bottom panel; left to right images, respectively). (d) Taenzer-Unna Orcein staining for elastin evaluation. No alterations were observed on elastin in the aorta of the control, HF and HFHSu animals (d, top panel; left to right images, respectively) nor in the PA of the control, HF and HFHSu animals (d, bottom panel; left to right images, respectively). Values are presented as mean ± SD. One-way ANOVA with Dunnet’s comparison test. **p < 0.01 versus control animals.

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