Figure 1 | Scientific Reports

Figure 1

From: A 14-gene gemcitabine resistance gene signature is significantly associated with the prognosis of pancreatic cancer patients

Figure 1

Identification of 14-gene signature and evaluation of the gene expression in multiple GEO datasets with different cell and clinical samples. (A) Venn diagram of the positive and negative gemcitabine resistance correlated genes derived from E-MTAB-3610 and CCLE datasets. (B) Venn diagram of identification of 22 survival related genes by Univariate Cox analysis via using E-MTAB-6134 and PACA-CA containing above gemcitabine resistance correlated genes and the clinical data. (C,D) Fourteen genes were identified by Lasso Cox regression analysis; Lasso coefficients profiles (C) and Lasso deviation profiles (D). Gene expression level evaluation of the 14 genes in GSE140077 (gemcitabine resistance cells; FPKM: Fragments Per Kilobase of transcript per Million mapped reads; (E), GSE62165 (PDAC and normal tissues; (F), GSE91035 (PDAC, benign and normal tissues; (G) and GSE19650 (multiple different pre-pancreatic carcinoma stage tissues; IPMA: intraductal papillary-mucinous adenoma; IPMC: intraductal papillary-mucinous carcinoma; IPMN: intraductal papillary-mucinous neoplasm; (H).

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