Figure 1 | Scientific Reports

Figure 1

From: Pathological findings after third- and second-generation everolimus-eluting stent implantations in coronary arteries from autopsy cases and an atherosclerotic porcine model

Figure 1

Pathology of human autopsy cases. (A–N) Representative images of human coronary arteries with implanted third-generation abluminal biodegradable-polymer everolimus-eluting stents (3rd EES, A–G) and second-generation durable-polymer everolimus-eluting stents (2nd EES, H–N). (A) Most struts of the 3rd EES are covered with neointima. (B–D) The neointima after 3rd EES implantation shows a well-developed matrix with tightly arranged smooth muscle cells. There is no infiltration of inflammatory cells. (E) The luminal surface is well-covered by endothelial cells (arrows). (F, G) Few fibrin deposits are observed around the 3rd EES struts. (H, J) Some struts of the 2nd EES are not covered. (I) Neointima after 2nd EES implantation consists of loose connective tissue. (K) Advanced inflammatory cell infiltration and fibrin deposits (arrows) are seen around the struts of the 2nd EESs. (L) Advanced inflammatory cell infiltration and neointima partially lacking endothelial cells (arrows) are shown. (M, N) Fibrin deposition is prominent around the 2nd EES struts. (O) Morphometrical analysis of the 3rd and the 2nd EES tissues. Although both 3rd and 2nd EESs show a high degree of coverage, the 3rd EES has better coverage. †p < 0.05. (C–E, G, I, J, M, N *; stent strut. A–E, H–L; hematoxylin–eosin. F, G, M, N; Masson’s trichrome).

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