Figure 2 | Scientific Reports

Figure 2

From: The cyclophilin inhibitor NIM-811 increases muscle cell survival with hypoxia in vitro and improves gait performance following ischemia–reperfusion in vivo

Figure 2

Laser Doppler imaging of female mice models of hindlimb ischemia. (A) Blood flow measurements of ischemic left hindlimbs in female vehicle (control)-treated mice subjected to 90 min ischemia the hindlimb baseline (pre-ischemia) flux, as well as the reperfusion flux, were significantly ****P = 0.0001 higher than ischemic flux. (B) Representative Laser Doppler images in control mice during baseline, ischemia, and reperfusion. (C) Blood flow measurements of ischemic left hindlimbs in female mice treated with NIM-811 subjected to 90 min ischemia the hindlimb baseline (pre-ischemia) flux as well as the reperfusion flux were significantly ****P = 0.0001 higher than ischemic flux. Moreover, the reperfusion flux was significant ***P = 0.0006 vs. baseline (pre-ischemia). (D) Representative Laser Doppler images in female mice treated with NIM-811 during baseline, ischemia, and reperfusion.

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