Figure 4 | Scientific Reports

Figure 4

From: The cyclophilin inhibitor NIM-811 increases muscle cell survival with hypoxia in vitro and improves gait performance following ischemia–reperfusion in vivo

Figure 4

Histology of muscle tissue. (A–D) Morphometric analysis of muscle fiber cross-sectional area of the TA muscles intact fibers in female and male mice does not differ significantly between the ischemic limbs of vehicle (control) and NIM-811 treated mice. (E–H) Hematoxylin and eosin (H&E)/ trichome sections of TA muscle fibers from the ischemic limbs of vehicle-treated female and male mice show some shrinkage, necrosis, and irregular morphology compared to non-ischemic limb from the same group. The muscle fiber morphology was more regular, and staining was more uniform from the ischemic limbs of NIM-811 treated mice, most of the muscle cell was still located in the muscle membrane, and degeneration less frequent compared to the non-ischemic limb from the same group. Scale bar = 100 μm.

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