Table 4 Enriched pathway analysis identified in COVID19 patients.

From: Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

Groups

Enriched metabolite set

Hits

p value

Holm P

FDR

C versus M

Glycine and serine metabolism

5

0.00103

0.101

0.0547

Valine, leucine and isoleucine degradation

5

0.00112

0.108

0.0547

Propanoate metabolism

4

0.00241

0.231

0.0786

Phenylalanine and tyrosine metabolism

3

0.00669

0.636

0.118

Urea cycle

3

0.0074

0.695

0.118

Warburg effect

4

0.00792

0.737

0.118

Malate-aspartate shuttle

2

0.00843

0.775

0.118

C versus S

Glutamate metabolism

3

0.0312

1.0

0.874

Glutathione metabolism

2

0.0358

1.0

0.874

Warburg effect

3

0.0483

1.0

0.874

M versus S

Valine, leucine and isoleucine degradation

4

0.00686

0.672

0.392

Citric acid cycle

3

0.00799

0.775

0.392

Glutathione metabolism

2

0.0314

1.0

0.655

Transfer of acetyl groups into mitochondria

2

0.0343

1.0

0.655

Warburg effect

3

0.0402

1.0

0.655

Glycine and serine metabolism

3

0.042

1.0

0.655

Cysteine metabolism

2

0.0468

1.0

0.655

C versus M versus S

Glutamate metabolism

3

0.0312

1.0

0.793

Glutathione metabolism

2

0.0358

1.0

0.793

Warburg effect

3

0.0483

1.0

0.793

  1. Results of the enrichment pathways according to Metaboanalyst (v4.0), employing the VIP values from PLS-DA analysis as the input metabolites.
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