Figure 3

Progression-free survival (PFS)/disease free survival (DFS) in the overall cohort (N = 154). Kaplan–Meier curves for comparisons of progression-free survival between (A) high cfDNA Ratio and low cfDNA Ratio groups, (B) high cfDNA baseline and low cfDNA baseline groups, (C) high post-therapy cfDNA and low post-therapy cfDNA groups (cut-values were set as median value), respectively. (D) The hazard ratios of cfDNA ratio and other important clinical factors by multivariate Cox model. Cut-values were set as the median value of the overall cohort, respectively. PFS/DFS was assessed according to Response Evaluation Criteria in Solid Tumors, version 1.1 through investigators’ review, and tick marks represent data censored at the last time the patient was known to be alive and without disease progression.