Table 3 Psychiatric symptoms and substance use in the MxGDAR subsample with different PRSs.
From: Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals
High PRS (n = 1950) | Medium PRS (n = 399) | Low PRS (n = 1044) | Statistic (p) | |
|---|---|---|---|---|
Polygenic risk scores | ||||
Comorbidity (Com-PRS) | 0.30 (1.07) | − 0.02 (0.37) | − 0.60 (0.73) | 15.63 (4.26e−10) |
Substance use (Subs-PRS) | 0.31 (1.08) | − 0.01 (0.35) | − 0.59 (0.69) | 11.58 (1.51e−07) |
Psychiatric (Psych-PRS) | 0.30 (1.05) | − 0.01 (0.35) | − 0.62 (0.72) | 13.34 (1.19e−08) |
Psychiatric symptoms | ||||
Hypo(mania) | 194 (9.95) | 46 (11.53) | 90 (8.62) | 3.50 (0.1740) |
Post-traumatic stress | 144 (7.38) | 28 (7.02) | 56 (5.36) | 4.38 (0.1118) |
Depression | 166 (8.51) | 31 (7.77) | 64 (6.13) | 5.23 (0.0733) |
Anxiety | 131 (6.72) | 16 (4.01) | 48 (4.60) | 7.53 (0.0232) |
Obsession/compulsion | 71 (3.64) | 10 (2.51) | 27 (2.60) | 2.85 (0.2396) |
Psychosis | 37 (1.90) | 4 (1.00) | 12 (1.15) | 3.19 (0.2028) |
Substance use | ||||
Alcohola | 765 (39.23) | 151 (37.84) | 332 (31.80) | 15.94 (3.45e−04) |
Tobaccob | 489 (25.08) | 92 (23.06) | 198 (18.97) | 13.73 (1.04e−03) |
Cannabis | 331 (16.97) | 57 (14.29) | 156 (14.94) | 2.42 (0.2978) |
Cocaine | 138 (7.08) | 24 (6.02) | 74 (7.09) | 0.40 (0.8174) |
Tranquilizers | 38 (1.95) | 10 (2.51) | 15 (1.44) | 2.18 (0.3366) |
Crack | 35 (1.79) | 8 (2.00) | 20 (1.92) | 0.17 (0.9186) |
Inhalants | 36 (1.85) | 9 (2.26) | 14 (1.34) | 1.83 (0.4003) |
Hallucinogens | 23 (1.18) | 4 (1.00) | 12 (1.15) | 0.06 (0.9722) |
Amphetamines | 14 (0.72) | 4 (1.00) | 8 (0.77) | 0.43 (0.8062) |
Heroin | 8 (0.41) | 3 (0.75) | 3 (0.29) | 1.63 (0.4434) |
Opioids | 4 (0.21) | 0 (0.00) | 5 (0.48) | 3.12 (0.2100) |
Sedatives | 4 (0.21) | 1 (0.25) | 1 (0.09) | 0.61 (0.7364) |
