Table 1 Relative bioavailability of LLL12 and LLL12B in mice dosed PO.

From: LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells

PK parameters

Unit ↓ (Dosage →)

LLL12

LLL12B

PO

PO

20 mg/kg

8 mg/kg

Tmax

hours

0.083

7.68

Cmax

nM

176

278

AUCall

nM*hr

40.7

1357

Bioavailability (F)

%

2.73

47.7

  1. per os (PO): by mouth or orally.
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