Table 2 Performance metrics of individual plasma proteins in addition to clinical covariates for prediction of all-cause mortality in the MDCS-CVA.

From: Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort

Model

C-statistic

P-value (LR)

IDI

P-value

cNRI

P-value

Clinical model*

0.7222

–

  

–

 

 + AR

0.7247

0.0001

0.0039

0.0001

0.1673

 < 0.0001

 + CXCL9

0.7243

0.0002

0.0033

0.0008

0.1439

 < 0.0001

 + HE4

0.7260

 < 0.0001

0.0058

 < 0.0001

0.1788

 < 0.0001

 + GH

0.7248

0.0001

0.0042

0.0002

0.1268

0.0006

 + GDF15

0.7284

 < 0.0001

0.0088

 < 0.0001

0.1287

0.0005

 + NTproBNP

0.7235

 < 0.0001

0.0044

0.0003

0.0569

0.1238

 + SCF

0.7253

 < 0.0001

0.0057

0.0001

0.1419

0.0001

 + UPAR

0.7266

 < 0.0001

0.0040

0.0002

0.1564

 < 0.0001

  1. LR likelihood ratio test, cNRI category-free Net Reclassification Improvement, IDI integrated discrimination improvement.
  2. *Cox regression model including age, sex, smoking status, BMI, educational level, history of hypertension, prevalent diabetes mellitus, C-reactive protein (ln-transformed), HbA1c (ln-transformed), and LDL-cholesterol.
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