Figure 6
Representative HRCT images with diffuse nodules and ground-glass attenuation. This patient was a 33-year-old female with S-LAM. HRCT showed diffuse nodules with diffuse ground-glass attenuation areas (A). She underwent lung biopsy by VATS to establish the diagnosis. Macroscopic view of the resected specimen showed brown-colored lung tissue with a few cystic lesions (B). Histopathological examination demonstrated numerous hemosiderin-laden macrophages in alveolar spaces and mild thickening of the alveolar walls with hemosiderin deposition in the interstitium (C: HE stain, original magnification × 192). Bundles of proliferating LAM cells with slit-like spaces were also found in the lung parenchyma (D: HE stain, original magnification × 162). LAM cells showed cytoplasmic positive immunostaining for α-SMA (E: original magnification × 195) and HMB45 (F: original magnification × 300).
