Table 2 Ranges MIC/MEC, Geometric mean MIC/MEC, Modal MIC/MEC, distribution of MICs/MECs of 10 antifungal agents against 48 Aspergillus isolates.

From: Identification and in vitro antifungal susceptibility of causative agents of onychomycosis due to Aspergillus species in Mashhad, Iran

Species (n)

Antifungal agent

MICs/MECs (mg/L)

No. of isolates with the MIC/MEC (mg/L) of

Ranges

MIC90/GM

 ≤ 0.008

0.015

0.03

0.063

0.125

0.25

0.5

1

2

4

8

16

A.flavus (38)

Amphotericin B

1–4

2/2.151

       

5

24

9

  

Itraconazole

0.25–1

0.5/0.311

     

27

10

1

    

Voriconazole

0.25–0.5

0.25/0.274

     

33

5

     

Posaconazole

0.03–0.5

0.5/0.097

  

13

9

5

 

11

     

Isavuconazole

0.125–0.5

0.5/0.274

    

4

25

9

     

Ravuconazole

0.25–0.5

0.5/0.394

     

13

25

     

Anidulafungin

0.008–0.015

0.008/0.008

36

2

          

Caspofungin

0.063–0.25

0.25/0.142

   

6

21

9

2

     

Micafungin

 ≤ 0.008

0.008/0.008

38

           

Terbinafine

0.03–0.063

0.03/0.03

  

35

3

        

A.minisclerotigenes (1)

Amphotericin B

1

ND

       

1

    

Itraconazole

0.25

ND

     

1

      

Voriconazole

0.25

ND

     

1

      

Posaconazole

0.5

ND

      

1

     

Isavuconazole

0.25

ND

     

1

      

Ravuconazole

0.5

ND

      

1

     

Anidulafungin

 ≤ 0.008

ND

1

           

Caspofungin

0.125

ND

    

1

       

Micafungin

 ≤ 0.008

ND

1

           

Terbinafine

0.03

ND

  

1

         

A.niger (1)

Amphotericin B

1

ND

       

1

    

Itraconazole

0.5

ND

      

1

     

Voriconazole

0.25

ND

     

1

      

Posaconazole

0.5

ND

      

1

     

Isavuconazole

0.5

ND

      

1

     

Ravuconazole

0.5

ND

      

1

     

Anidulafungin

 ≤ 0.008

ND

1

           

Caspofungin

0.125

ND

    

1

       

Micafungin

 ≤ 0.008

ND

1

           

Terbinafine

0.03

ND

  

1

         

A. welwitschiae (1)

Amphotericin B

0.5

ND

      

1

     

Itraconazole

0.5

ND

      

1

     

Voriconazole

0.25

ND

     

1

      

Posaconazole

0.5

ND

      

1

     

Isavuconazole

0.25

ND

     

1

      

Ravuconazole

0.25

ND

     

1

      

Anidulafungin

 ≤ 0.008

ND

1

           

Caspofungin

0.125

ND

    

1

       

Micafungin

 ≤ 0.008

ND

1

           

Terbinafine

0.03

ND

  

1

         

A.tubingensis (2)

Amphotericin B

0.25–1

ND

     

1

 

1

    

Itraconazole

1

ND

       

2

    

Voriconazole

0.25

ND

     

2

      

Posaconazole

0.25–1

ND

     

1

 

1

    

Isavuconazole

0.5–1

ND

      

1

1

    

Ravuconazole

0.5–1

ND

      

1

1

    

Anidulafungin

 ≤ 0.008

ND

2

           

Caspofungin

0.063–0.125

ND

   

1

1

       

Micafungin

 ≤ 0.008

ND

2

           

Terbinafine

0.03–0.5

ND

  

1

   

1

     

A. terreus (3)

Amphotericin B

0.5–1

1/0.794

      

1

2

    

Itraconazole

0.25–0.5

0.5/0.397

     

1

2

     

Voriconazole

0.25–0.5

0.5/0.315

     

2

1

     

Posaconazole

0.063–0.125

0.125/0.0792162

   

2

1

       

Isavuconazole

0.25–0.5

0.5/0.397

     

1

2

     

Ravuconazole

0.25–0.5

0.5/0.397

     

1

2

     

Anidulafungin

 ≤ 0.008

0.008/0.008

3

           

Caspofungin

0.25

0.25/0.25

     

3

      

Micafungin

 ≤ 0.008

0.008/0.008

3

           

Terbinafine

0.25

0.25/0.25

     

3

      

A.citrinoterreus (1)

Amphotericin B

4

ND

         

1

  

Itraconazole

0.25

ND

     

1

      

Voriconazole

0.25

ND

     

1

      

Posaconazole

0.03

ND

  

1

         

Isavuconazole

0.125

ND

    

1

       

Ravuconazole

0.125

ND

    

1

       

Anidulafungin

 ≤ 0.008

ND

1

           

Caspofungin

0.25

ND

     

1

      

Micafungin

 ≤ 0.008

ND

1

           

Terbinafine

0.25

ND

     

1

      

A. ochraceus (1)

Amphotericin B

2

ND

        

1

   

Itraconazole

0.25

ND

     

1

      

Voriconazole

0.5

ND

      

1

     

Posaconazole

0.03

ND

  

1

         

Isavuconazole

0.5

ND

      

1

     

Ravuconazole

0.5

ND

      

1

     

Anidulafungin

 ≤ 0.008

ND

1

           

Caspofungin

0.25

ND

     

1

      

Micafungin

 ≤ 0.008

ND

1

           

Terbinafine

0.03

ND

  

1

         
  1. Abbreviations: minimum inhibitory concentration, MIC;minimum effective concentration, MEC; values in bold indicate modal or most frequent MICs, Modal MIC/MEC; MICs are shownfor amphotericin B, itraconazole, posaconazole, voriconazole, ravuconazole, isavuconazole; MECs are shown for micafungin, caspofungin and anidulafungin.ND: not determined.
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