Figure 4
From: The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation
Hypothetical model showing a dual role for nickel (Ni) and a proposed mode of action for DMG-mediated Ni chelation. Ni can bind to Aβ peptides, leading to aggregation and plaque formation (left side, metal hypothesis of AD). In addition, Ni is required as cofactor for enzymes (such as hydrogenase and urease) of pathogens previously shown to play a role in Aβ peptide aggregation (right side, infection hypothesis of AD). The Ni-chelator DMG could inhibit Aβ peptide aggregation and the progression of AD (red crosses), either directly (left side) or indirectly (through pathogen inhibition, right side).
