Table 1 Baseline donor characteristics and circulating levels of IL-6 and CXCL10.
From: Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes
Variable | IL-6 | CXCL10 | ||||
|---|---|---|---|---|---|---|
Median (IQR) | p | Median (IQR) | p | |||
Yes | No | Yes | No | |||
Demographic and health history | ||||||
Age | ρa = 0.136 | < 0.001 | ρ = 0.077 | 0.01 | ||
Male | 338 (109–973) | 259 (93–846) | 0.073 | 1,277 (662–2,392) | 1,148 (615–2,207) | 0.208 |
Weight | ρ = 0.034 | 0.256 | ρ = 0.03 | 0.322 | ||
BMI | ρ = 0.031 | 0.310 | ρ = 0.008 | 0.792 | ||
Diabetes | 369 (126–1075) | 267 (100–854) | 0.033 | 1241 (660–2384) | 1189 (622–2273) | 0.695 |
Hypertension | 328 (120–10,779 | 254 (87–776) | 0.007 | 1242 (680–2382) | 1143 (585–2204) | 0.049 |
Cardiomyopathy | 339 (134–1017) | 250 (91–930) | 0.017 | 1429 (758–2519) | 1022 (534–2077) | < 0.001 |
Cancer | 358 (155–1443) | 286 (102–841) | 0.067 | 1561 (714–3222) | 1155 (625–2252) | 0.084 |
Smoke | 1118 (603–2108) | 1219 (652–2276) | 0.362 | 268 (89–836) | 289 (114–871) | 0.116 |
Alcohol abuse | 1317 (648–2752) | 1160 (621–2228) | 0.373 | 372 (136–953) | 271 (101–834) | 0.761 |
Cause of death | ||||||
Cause of death: cardiovascular | 274 (97–964) | 325 (105–875) | 0.651 | 1144 (615–2145) | 1325 (700–2583) | 0.015 |
Cause of death: trauma | 362 (124–851) | 271 (93–942) | 0.181 | 1125 (616–2264) | 1227 (641–2284) | 0.433 |
Cause of death: anoxic event | 282 (69–911) | 296 (103–934) | 0.381 | 1809 (933–3457) | 1149 (619–2222) | < 0.001 |
Cause of death: brain tumour | 482 (76–1856) | 293 (101–932) | 0.643 | 1549 (637–3770) | 1219 (634–2284) | 0.494 |
Cause of death: others | 242 (96–784) | 302 (102–942) | 0.684 | 1154 (710–2687) | 1222 (630–2268) | 0.631 |
Intensive care duration and hemodynamic stability | ||||||
Lengths of stay in ICU | ρ = 0.02 | 0.507 | ρ = 0.251 | < 0.001 | ||
Any inotrope administered | 341 (118–99) | 140 (64–287) | < 0.001 | 1235 (660–2372) | 846 (480–1701) | < 0.001 |
Two or more inotropes | 402 (140–1603) | 264 (97–788) | < 0.001 | 140 (799–3133) | 1132 (599–2174) | 0.001 |
Number of inotropes | ρ = 0.204 | < 0.001 | ρ = 0.153 | < 0.001 | ||
Norepinephrine administered | 359 (124–1094) | 223 (91–596) | < 0.001 | 1237 (662–2324) | 1115 (577–2118) | 0.085 |
Dopamine administered | 307 (112–819) | 275 (99–950) | 0.472 | 1224 (666–2443) | 1159 (596–2219) | 0.111 |
Cardiac arrest | 272 (103–875) | 276 (103–875) | 0.696 | 1324 (686–2475) | 1100 (609–2183) | 0.019 |
Biochemistry blood tests | ||||||
Blood type A | 290 (102–791) | 299 (101–1,017) | 0.437 | 1,149 (665–2259) | 1,242 (622–2333) | 0.743 |
Blood type B | 274 (118–777) | 302 (100–933) | 0.959 | 1104 (619–1788) | 1233 (634–2324) | 0.222 |
Blood type AB | 185 (95–651) | 302 (102–935) | 0.394 | 1237 (641–3081) | 1219 (630–2264) | 0.698 |
Blood type 0 | 322 (95–1114) | 280 (102–789) | 0.259 | 1292 (615–2363) | 1149 (653–2239) | 0.385 |
Proteinuria during admission | 292 (112–727) | 313 (107–953) | 0.96 | 1237 (656–2475) | 1154 (613–2188) | 0.199 |
Final WBC | ρ = -0.161 | < 0.001 | ρ = -0.097 | 0.006 | ||
Final Hb | ρ = 0.001 | 0.976 | ρ = -0.031 | 0.393 | ||
Final creatinine | ρ = 0.194 | < 0.001 | ρ = 0.21 | < 0.001 | ||
Final blood urea nitrogen | ρ = 0.055 | 0.151 | ρ = 0.179 | < 0.001 | ||
Final AST | ρ = -0.055 | 0.126 | ρ = 0.051 | 0.158 | ||
Final ALT | ρ = -0.091 | 0.087 | ρ = 0.068 | 0.057 | ||
Total bilirubin | ρ = 0.164 | < 0.001 | ρ = 0.131 | < 0.001 | ||
Final GGT | ρ = -0.045 | 0.226 | ρ = 0.138 | < 0.001 | ||
Final amylase | ρ = 0.103 | 0.010 | ρ = 0.035 | 0.381 | ||
Final international normalized ratio | ρ = 0.166 | < 0.001 | ρ = 0.163 | < 0.001 | ||
Infectious disease data | ||||||
Donor urinary infection | 404 (117–1268) | 263 (92–841) | 0.030 | 404 (117–1268) | 263 (92–841) | 0.040 |
Donor blood infection | 341 (101–2086) | 270 (95–822) | 0.039 | 1509 (853–3063) | 1152 (615–2142) | 0.003 |
Donor pulmonary infection | 311 (102–993) | 251 (88–803) | 0.107 | 1242 (641–2168) | 1104 (609–2150) | 0.221 |
HBcAb positive | 324 (118–866) | 287 (97–946) | 0.419 | 1219 (656–2251) | 1221 (631–2291) | 0.803 |
HCV positive | 304 (83–1279) | 296 (102–932) | 0.867 | 1527 (814–4412) | 1208 (628–2259) | 0.072 |
EBV-EBNA IgG positive | 312 (103–944) | 235 (80–717) | 0.193 | 1228 (634–2333) | 1043 (622–2039) | 0.181 |
EBV-VCA IgG positive | 310 (103–950) | 203 (82–580) | 0.045 | 1221 (633–2288) | 1086 (619–2351) | 0.520 |
CMV-IgG positive | 311 (104–951) | 229 (83–690) | 0.057 | 1219 (634–2294) | 1265 (604–2264) | 0.602 |
CMV-IgM positive | 3346 (2590–4103) | 290 (101–932) | 0.037 | 3110 (2204–4017) | 1203 (633–2272) | 0.127 |
HSV-1 IgG positive | 287 (102–942) | 312 (82–788) | 0.639 | 1221 (632–2321) | 1272 (649–1978) | 0.597 |
HSV-2 IgG positive | 229 (90–731) | 311 (102–946) | 0.205 | 1179 (646–2247) | 1219 (632–2291) | 0.6 |
Toxo-IgG positive | 270 (92–797) | 323 (111–973) | 0.079 | 1222 (640–2316) | 1162 (610–2233) | 0.697 |
Toxo-IgM positive | 323 (66–503) | 297 (102–934) | 0.673 | 1365 (847–2610) | 1208 (633–2284) | 0.567 |
TPHA positive | 149 (83–864) | 299 (102–934) | 0.492 | 839 (523–2291) | 1221 (634–2291) | 0.309 |
VZV-IgG positive | 299 (102–926) | 288 (86–989) | 0.885 | 1220 (622–2305) | 1187 (703–2111) | 0.954 |
