Table 3 Clinicopathological features selection using the univariable and multivariate Cox logistic regression model among the training group.

From: Development and validation for prognostic nomogram of epithelial ovarian cancer recurrence based on circulating tumor cells and epithelial–mesenchymal transition

Variables

Univariate analysis

Multivariate analysis

Hazard ratio

95% CI*

p-value

Hazard ratio

95% CI*

p-value

Age (years)

1.131

1.028–1.954

0.045

1.089

0.922–1.317

0.058

BMI (kg/m2)

1.016

0.969–1.064

0.514

–

–

–

Tumor size (cm)

1.271

1.014–1.298

0.048

0.933

0.815–1.069

0.314

Menopausal status

 Pre/peri-menopause

Reference

–

–

Reference

–

–

 Post-menopause

1.153

1.037–1.209

0.047

3.498

0.196–6.374

0.394

Fertility history

 0–1

Reference

–

–

–

–

–

 ≥ 2

0.989

0.967–1.025

0.574

–

–

–

Pathological grade

 G1–2

Reference

–

–

Reference

–

–

 G3

1.509

1.031–4.506

0.034

1.382

1.104–3.965

0.041

FIGO stage

 I–II

Reference

–

–

Reference

–

–

 III–IV

2.534

1.293–4.966

0.007

2.391

1.230–4.377

0.011

Lymph node metastasis

 Negative

Reference

–

–

Reference

–

–

 Positive

1.269

1.045–3.582

0.036

1.312

1.029–2.975

0.039

Ascites

 Negative

Reference

–

–

Reference

–

–

 Positive

1.123

1.042–1.301

0.017

1.215

1.067–1.806

0.026

CTC counts (n/5 mL)

1.241

1.108–1.384

0.009

1.187

1.098–1.752

0.012

M-CTC (n %)

1.147

1.051–1.288

0.006

1.098

1.047–1.320

0.009

E-CTC (n %)

0.983

0.857–2.694

0.148

–

–

–

Hybrids-CTC (n %)

1.058

0.894–1.753

0.365

–

–

–

Neutrophil (109/L)

1.015

0.992–1.038

0.207

–

–

–

Lymphocyte (109/L)

1.066

0.888–1.278

0.494

–

–

–

Platelet (109/L)

1.002

0.997–1.007

0.351

–

–

–

Albumin (g/L)

0.909

0.849–0.972

0.025

1.027

0.980–1.077

0.266

CA-125 (U/mL)

1.101

1.002–1.203

0.019

1.097

1.021–1.373

0.028

CA-199 (U/mL)

0.977

0.942–1.012

0.198

–

–

–

AFP (ng/mL)

1.001

0.963–1.040

0.958

–

–

–

CEA (ng/mL)

1.001

0.999–1.012

0.805

–

–

–

HE4 (pmol/L)

1.217

1.104–1.232

0.039

0.959

0.850–1.081

0.489

  1. BMI Body Mass Index, FIGO the International Federation of Gynecology and Obstetrics, CTC circulating tumor cell, M-CTC mesenchymal CTCs/ total CTCs percentage, E-CTC epithelial CTCs/ total CTCs percentage, Hybrids-CTC hybrids CTCs/ total CTCs percentage, CA-125 carbohydrate antigen-125, CA-199 carbohydrate antigen-199, CEA carcinoembryonic antigen, AFP alpha-fetoprotein, HE4 human epididymis protein 4.
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