Table 1 OMN6 minimum inhibitory concentration results on 21 clinical isolates of Gram (−) and Gram (+) bacteria. Bacteria were subjected to Minimal Inhibitory Concentration (MIC) tests by broth microdilution method (CLSI guidelines). Resistance pattern of the different isolates is presented in the last column according to the following abbreviations: MDR multidrug resistant, Col-S colistin-sensitive, Col-R colistin-resistant, Mer-S meropenem sensitive, Mer-R meropenem resistant, S sensitive, mcr-1 mobilized colistin resistance gene 1, MSSA methicillin-sensitive Staphylococcus aureus, MRSA methicillin-resistant Staphylococcus aureus, Van-S vancomycin sensitive, Van-R vancomycin resistant, N/A data not available. Supplementary information about the resistance pattern of most bacterial strains used in this study is displayed in Tables S1 and S2.
From: OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria
Bacteria | Strain | MIC (µg/mL) | Resistance pattern |
|---|---|---|---|
Acinetobacter baumannii Gram (−) | ACC 00445 | 4 | MDR/Col-S |
ACC 00527 | 4 | MDR/Col-R | |
ACC 00535 | 4 | MDR/Col-S | |
ATCC 17978 | 8 | S | |
ATCC 19606 | 8 | S | |
ACC 01076 | 8 | MDR/Col-R | |
ACC 01077 | 4 | MDR/Col-R | |
NCTC 13420 | 4 | N/A | |
ATCC BAA-1793 | 8 | MDR | |
JMI #1088100 | 8 | Col-S/Mer-S | |
JMI #1001007 | 4 | Col-R/Mer-R | |
Klebsiella pneumonia Gram (−) | ATCC 43816 | 16 | S |
ATCC BAA-1705 | 16 | MDR | |
Escherichia coli Gram (−) | ATCC 25922 | 16 | S |
ACC 01001 | 32 | mcr-1 | |
Staphylococcus aureus Gram (+) | ATCC 29213 | > 256 | MSSA |
ATCC 33591 | > 256 | MRSA | |
ATCC BAA-44 | > 256 | MDR/MRSA | |
Bacillus cereus Gram (+) | ATCC 14579 | > 256 | N/A |
Enterococcus faecalis Gram (+) | ATCC 29212 | > 256 | Van-S |
Enterococcus faecium Gram (+) | ATCC BAA-2319 | > 256 | MDR/Van-R |
