Table 2 Haplotype tests of association showing ERAP2 C–C–G haplotype associated with preeclampsia.

From: Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women

Haplotypes

Haplotype frequency

Control

PE

PEsuper

Eclampsia

HELLP

ERAP1

T–G

0.354

0.358

0.328

0.341

0.323

T–C

0.105

0.097

0.121

0.051

0.074

C–C

0.541

0.545

0.552

0.609

0.602

ERAP2

C–T–A

0.362

0.361

0.356

0.301

0.352

C–C–A

0.064

0.066

0.060

0.065

0.079

C–C–G

0.045

0.076a

0.050

0.045

0.065

T–C–G

0.488

0.482

0.515

0.523

0.452

LNPEP

T–C–A

0.123

0.130

0.105

0.132

0.135

C–T–G

0.398

0.376

0.375

0.345

0.397

T–C–G

0.479

0.494

0.520

0.521

0.468

  1. ERAP1: rs30187–rs27044.
  2. ERAP2: rs2549796–rs2927609–rs11135484.
  3. LNPEP: rs27300–rs38034–rs2303138.
  4. aPE versus Control (Uncorrected p = 0.0013; p-value corrected for family-wise error rates by running 10,000 permutations: p = 0.0109).
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