Table 1 Comparison of patient characteristics between patients with ADX and MRA.

From: Age-stratified comparison of clinical outcomes between medical and surgical treatments in patients with unilateral primary aldosteronism

 

Older (Age ≥ 65 y)

Younger (Age < 65 y)

ADX N = 96

MRA N = 57

p-value

ADX N = 526

MRA N = 176

p-value

Baseline characteristics

Age, years

67 (65–70)

68 (66–72)

0.18

50 (40–57)

53 (46–60)

 < 0.01

Female, n (%)

37 (39)

31 (54)

0.07

263 (50)

67 (38)

 < 0.01

BMI, kg/m2

23.7 ± 3.69

23.6 ± 3.27

0.99

24.2 ± 4.11

25.4 ± 4.16

 < 0.01

SBP, mmHg

143.3 ± 18.3

142.1 ± 15.8

0.69

141.3 ± 18.9

142.6 ± 17.5

0.42

DBP, mmHg

81.1 ± 12.5

81.0 ± 11.9

0.95

87.7 ± 12.1

88.3 ± 12.7

0.62

eGFR, mL/min/1.73m2

67.4 ± 17.4

66.6 ± 17.4

0.80

81.6 ± 22.9

76.4 ± 17.3

 < 0.01

Duration of HT, years

19 (10–26)

15 (6–23)

0.052

7 (2–12)

7 (3–15)

0.51

Hypokalemia, n (%)

77 (80)

28 (49)

 < 0.01

409 (78)

91 (52)

 < 0.01

Proteinuria, n (%)

22 (24) (n = 91)

17 (31) (n = 55)

0.37

90 (18) (n = 497)

25 (15) (n = 167)

0.41

PA characteristics

Lateralization index

12.7 (7.5–27.3)

6.9 (4.2–12.8)

 < 0.01

12.1 (6.1–26.8)

6.2 (3.4–13.4)

 < 0.01

PRA, ng/mL/h

 Baseline

0.2 (0.1–0.4)

0.2 (0.1–0.4)

0.53

0.3 (0.2–0.4)

0.3 (0.2–0.5)

0.01

 6 or 12 months

0.7 (0.4–1.4) (n = 70)

0.4 (0.3–1.3) (n = 25)

 < 0.01

1.1 (0.5–2.2) (n = 409)

0.8 (0.4–1.6) (n = 122)

 < 0.01

PAC, pg/mL

 Baseline

281 (181–396)

186 (139–286)

 < 0.01

316 (211–469)

195 (147–314)

 < 0.01

 6 or 12 months

80 (57–123) (n = 74)

299 (170–465) (n = 28)

 < 0.01

99 (72–136) (n = 421)

268 (183–391) (n = 128)

 < 0.01

  1. Values are mean ± standard deviation, median (interquartile range), or n (%). ADX, adrenalectomy; ARR, aldosterone-renin ratio; BMI, body mass index; DBP, diastolic blood pressure; DDD, defined daily dose; eGFR, estimated glomerular filtration rate; HT, hypertension; MRA, mineralocorticoid receptor antagonist; PAC, plasma aldosterone concentration; PRA, plasma renin activity; SBP, systolic blood pressure.
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