Figure 3 | Scientific Reports

Figure 3

From: Prediction of disease flare by biomarkers after discontinuing biologics in patients with rheumatoid arthritis achieving stringent remission

Figure 3

Plasma cytokine profile at baseline as a predictive marker of RA flare after bDMARD discontinuation. (A) Comparison of patients with sTNFR1 ≤ cut-off (n = 20, solid line) and sTNFR1 > cut-off (n = 14, dotted line). (B) Comparison of patients with IL-2 > cut-off (n = 12, solid line) and IL-2 ≤ cut-off (n = 8, dotted line) in those with sTNFR1 ≤ cut-off (n = 20). (C) Comparison of patients with IL-2 > cut-off (n = 7, solid line) and IL-2 ≤ cut-off (n = 7, dotted line) in those with sTNFR1 > cut-off (n = 14). bDMARD biological disease-modifying antirheumatic drug, RA rheumatoid arthritis, sTNFR1 soluble tumour necrosis factor receptor 1, IL interleukin.

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