Table 3 Differential abundance testing for predicted metabolic content and pathways.

From: Esophageal microbiome in active eosinophilic esophagitis and changes induced by different therapies

 

BH-adjusted p-values (FDR)

EC 1.8.2

PWY.5022

PWY.6470

GLUTORN.PWY

ARGSYN.PWY

Controls vs. EoE baseline

ns

0.248

ns

0.129

0.241

Controls vs. post-FED

ns

0.175

ns

ns

ns

Controls vs. post-PPI

ns

0.190

ns

ns

ns

Controls vs. post-STC

ns

ns

ns

0.229

ns

Pre-STC vs. post-STC

0.082

ns

ns

ns

ns

Post-STC vs. post-FED

0.048

ns

0.155

ns

ns

Post-STC vs. post-PPI

0.060

ns

ns

ns

ns

  1. Only reactions (Enzyme Commision number; EC) and pathways (PWY) with at least one significant difference between groups according to adjusted p < 0.1 and p < 0.25 (Benjamini–Hochberg correction), respectively, are shown. BH: Benjamini–Hochberg correction; FDR: false discovery rate; EC 1.8.2: sulphur-cytochrome oxidoreductases; PWY.5022: 4-aminobutanoate degradation; PWY.6470: peptidoglycan biosynthesis V (β-lactam resistance); GLUTORN.PWY: L-ornithine biosynthesis I; ARGSYN.PWY: L-arginine biosynthesis II; EoE: eosinophilic oesophagitis; FED: food-elimination diet; PPI: proton pump inhibitors; STC: swallowed topical corticosteroids; ns: not significant (p > 0.1 for EC and p > 0.25 for PWY).