Table 2 Incidence of amputation and other vascular outcomes, mortality rate and costs per day among new users of SLGT-2 inhibitors, DPP-4 inhibitors, GLP-1 agonists, or other oral treatments for type 2 diabetes.
Cohort | SGLT-2 | DPP-4 | GLP-1 | Other |
|---|---|---|---|---|
First cohort (excluding amputation during baseline) | ||||
Amputation, No | 1 | 82 | 1 | 171 |
Total No. of person-years | 6,507.4 | 178,188.1 | 1,634.8 | 898,430.2 |
Rate per 10 000 person-years | 1.5 | 4.6 | 6.1 | 1.9 |
Observation time, median (IQR), days | 310 (90–464) | 453 (255–488) | 439.5 (151–480) | 422 (116–481) |
Death | 7 | 1,246 | 3 | 4,713 |
Total No. of person-years | 6,507.9 | 178,221.1 | 1,635.0 | 898,513.5 |
Rate per 10 000 person-years | 10.8 | 69.9 | 18.3 | 52.5 |
Observation time, median (IQR), days | 310 (90–464) | 453 (255–488) | 439.5 (151–480) | 422 (116–481) |
Cost | ||||
Total cost per day | 235 | 253 | 364 | 174 |
Emergency cost per day | 3 | 6 | 6 | 6 |
Inpatient cost per day | 37 | 46 | 24 | 36 |
Observation time, median (IQR), days | 310 (90–464) | 453 (255–488) | 439.5 (152–480) | 422 (116–481) |
Second cohort (excluding any outcome during baseline) | ||||
Ulcer, No | 10 | 303 | 3 | 1,167 |
Total No. of person-years | 6,294.1 | 170,468.9 | 1,577.7 | 867,221.7 |
Rate per 10,000 person-years | 15.9 | 17.8 | 19.0 | 13.5 |
Observation time, median (IQR), days | 310 (90–464) | 453 (254–488) | 440 (153–480) | 420 (114–481) |
Osteomyelitis | 7 | 171 | 3 | 708 |
Total No. of person-years | 6,295.2 | 170,538.1 | 1,577.0 | 867,487.5 |
Rate per 10,000 person-years | 11.1 | 10.0 | 19.0 | 8.2 |
Observation time, median (IQR), days | 310 (90–464) | 453 (254–488) | 440 (154–480) | 420 (115–481) |
Peripheral vascular disease | 71 | 2,257 | 16 | 10,999 |
Total No. of person-years | 6,257.6 | 169,326.0 | 1,569.3 | 861,726.2 |
Rate per 10,000 person-years | 113.5 | 133.3 | 102.0 | 127.6 |
Observation time, median (IQR), days | 304 (90–464) | 452 (252–487) | 439 (152–480) | 415 (112–481) |
Critical limb ischemia | 0 | 31 | 1 | 97 |
Total No. of person-years | 6,298.4 | 170,622.8 | 1,577.7 | 867,799.1 |
Rate per 10,000 person-years | 0.0 | 1.8 | 6.3 | 1.1 |
Observation time, median (IQR), days | 310 (90–464) | 453 (255–488) | 440 (154–480) | 420 (115–481) |
