Figure 5
DE genes show enrichment for CeD loci. (A) Genes prioritized from CeD loci30 were overlapped with DE genes and plotted per CeD locus. Log2 fold change between timepoints is indicated, and clusters are depicted with colored boxes (right). (B) Enrichment of DE genes over the null distribution (histogram) in CeD loci (± 125 kb window around start and end of gene) using GREA19 for all DE genes (n = 3509). X-axis indicates the number of genes that overlap with CeD loci as a percentage. The histogram shows the null distribution based on 10,000 permuted gene-sets. The black line indicates the value of the true gene-set. Nominal p values are indicated. (C) As in (B), but only for genes in cluster 3 (n = 1002).
