Figure 6 | Scientific Reports

Figure 6

From: CRISPR/Cas9 generated knockout mice lacking phenylalanine hydroxylase protein as a novel preclinical model for human phenylketonuria

Figure 6The alternative text for this image may have been generated using AI.

Cataract in Hom mice. (A) Note hypermature cataract characterized by collapsed and fragmented lens with the wrinkled capsule and formation of amorphous non-hyalinized core surrounded by protein globules in a Hom mouse as compared to the Het mouse. H&E stain. 1×. Higher magnification of lens showing disorganized, fragmented, and swollen lens fibers forming Morgagnian globules and hypereosinophilic condensed core in Hom mouse (B). H&E stain. 20×. (C) Summary of cataract score is shown in the scatter plot graph. n = 7 Hom, 7 Het. Bars indicate group median score and the error bars indicate range (***p = 0.0006).

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