Table 3 Systematic review of the results of the studies assessing preventive treatment for POI.

From: Comparison of treatment to improve gastrointestinal functions after colorectal surgery within enhanced recovery programmes: a systematic review and meta-analysis

First author

Unity

Time to FF (ref)

Time to FF (exp)

Time to FBM (ref)

Time to FBM (exp)

POI (%) (ref)

POI (%) (exp)

Lim et al.44

 

50.97 ± 3.79

42.75 ± 3.92

98.61 ± 7.06

89.64 ± 5.94

–

–

Zaghyian et al.43

Hours

47.4 (29.4)

48.6 (33.4)

63.2 (41.9)

56.9 (37.8)

6.6%

7.4%

Byrne et al.42

Hours

58.0 (42.0–74.0

42.0 (36.4–47.6)

80.0, 67.2–92.8

50.0, 45.2–54.8

17%

10%

Shum et al.40

Hours

34 (7–144)

18 (5–90)

44 (9–152)

19 (5–81)

–

–

Yang et al.41

Hours

64.1 (24.8–71.3)

62.3 (21.4–70.5) (CG)

75.2 (29.0–241.6)

119.3 (31.5–211.4) CG)

–

–

Atkinson et al.45

Days

2 (1–3)

2 (2–3)

3 (1–4)

2 (1–3)

14.1%

9.4%

Itawi et al.35

 

–

–

–

–

20%

2%

Ludwig et al.34

 

–

–

–

–

-

-

Barletta et al.37

 

–

–

–

–

21.7%

16.4%

Obokhare et al.33

 

–

–

–

–

12%

4%

Wen et al.38

 

–

–

–

–

10.3%

3.4%

Adam et al.36

 

–

–

–

–

16%

5%

Hyde et al.32

 

–

–

–

–

16.2%

10.8%

Keller et al.39

 

–

–

–

–

2.2%

2.2%

Müller et al.46

Hours

46.4 (20.1)

40.6 (16.1)

74.0 (21.6)

60.4 (21.3)

–

–

Hasler-Gehrer et al.47

Hours

31 (25–46)

40 (29–52)

74.1 (60.7–87.5)

65.2 (50.5–79.8)

–

–

Dulskas et al.48

Days

1.57

1.77 (Coffee)

4.14 (± 1.15)

3.75 (± 1.53)

–

–

Springer et al.53

Hours

37.9 ± 23.9

37.6 ± 26.7

41.1 ± 28.2

42.1 ± 25.2

4.7%

3.5%

Danelich et al.56

 

–

–

31.8 (22.5–54.4)

52.9 (45.3–82.4)

15.7%

20.5%

Andersen et al.51

 

14.0 (6–46)

18.0 (6–62)

50.0 (6–70)

42.0 (14–110)

–

–

Raju et al.55

 

–

–

–

–

13.4%

7.23%

Lohsiriwat et al.54

 

–

–

3 (3–4)

2 (2–3)

8%

5%

Singh et al.57

 

1 (1–3)

2 (1–2)

4 (1–5)

4 (2–7)

22%

18%

Gong et al.52

 

73.0 (7–305)

51.0 (26–129)

94.5 (27–315)

64.0 (25–172)

35.7%

17.8%

Popescu et al.49

 

2.85

_2.31, 2.93_

2.20

_1.92, 2.80_

–

–

0

4.2%

Falken et al.50

days

3.5 (± 0.4)

2.1 (± 3)

–

–

–

–

Venara et al.59

days

2.16 ± 0.32

1.47 ± 0.19

–

–

42%

6.1%

  1. Bold indicate significant difference.
  2. FF: time to first flatus, FBM: time to first bowel motion, POI: postoperative ileus, Exp: experimental, Ref : reference, N: none, P: placebo, CG: chewing gum.
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