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Figure 1

From: Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase

Figure 1

Wnt5a increases the PSD length in hippocampal slices. (a) EM images from the CA1 region of hippocampal slices exposed to Wnt5a conditioned medium for 30, 60 and 120 min. Scale bar = 250 nm. We include 4 different images for each condition. Wnt5a induced a time-dependent increase in the average PSD length (b) and area (c) in dendritic spines, with a reduction at 2 h. The spine head size was increased after 30 to 120 min of Wnt5a exposure (d) and the PSD area/spine size ratio (e) was induced at 30 min of Wnt5a treatment. N = 3 independent animals; Control (368); 30 (291); 60(247); 120(371) synaptic contacts. (***p = 0.00009).

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