Table 1 Frequencies of rs5186, rs1800629, rs1799983 and rs1800795 variant alleles and haplotypes in world populations.

From: Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins

SNP ID

rs5186

rs1800629

rs1799983

rs1800795

Haplotype (rs1800795_rs1799983)

Gene

AGTR1

TNFA

NOS3

IL-6

Chr:position

chr3: 148459988

chr7: 150696111

chr7: 150696111

chr7: 22766645

Major allele

A

G

G

G

Minor allele

C

A

T

C

Functional consequence

3′ prime UTR variant

Upstream transcript variant

Missense variant

Upstream transcript variant

Super-population

Sub-population

Minor (variant) allele frequency

All populations (ALL)*

All populations (ALL)

0.118

0.090

0.176

0.141

G_G

G_T

C_G

C_T

African (AFR)

African (AFR)

0.020

0.120

0.070

0.018

0.914

0.068

0.016

0.002

Yoruba in Ibadan, Nigeria (YRI)

0.014

0.102

0.056

0.000

0.944

0.056

  

Luhya in Webuye, Kenya (LWK)

0.005

0.086

0.035

0.000

0.965

0.035

  

Gambian in Western Divisions in the Gambia (GWD)

0.013

0.142

0.075

0.004

0.920

0.075

0.004

 

Mende in Sierra Leone (MSL)

0.012

0.159

0.047

0.000

0.953

0.047

  

Esan in Nigeria (ESN)

0.005

0.126

0.101

0.000

0.899

0.101

  

Americans of African Ancestry in SW USA (ASW)

0.090

0.074

0.107

0.090

0.803

0.107

0.090

 

African Caribbeans in Barbados (ACB)

0.031

0.135

0.083

0.063

0.870

0.068

0.047

0.016

Admixed American (AMR)

Admixed American (AMR)

0.233

0.069

0.215

0.184

0.654

0.161

0.131

0.053

Mexican Ancestry from Los Angeles USA (MXL)

0.266

0.055

0.195

0.133

0.703

0.164

0.102

0.031

Puerto Ricans from Puerto Rico (PUR)

0.212

0.087

0.284

0.231

0.572

0.197

0.144

0.087

Colombians from Medellin, Colombia (CLM)

0.207

0.069

0.266

0.287

0.527

0.207

0.186

0.080

Peruvians from Lima, Peru (PEL)

0.265

0.059

0.088

0.053

0.859

0.088

0.053

 

East Asian (EAS)

East Asian (EAS)

0.060

0.059

0.130

0.001

0.869

0.130

0.001

 

Han Chinese in Beijing, China (CHB)

0.053

0.092

0.136

0.000

0.864

0.136

  

Japanese in Tokyo, Japan (JPT)

0.063

0.019

0.082

0.000

0.918

0.082

  

Southern Han Chinese (CHS)

0.091

0.057

0.148

0.000

0.852

0.148

  

Chinese Dai in Xishuangbanna, China (CDX)

0.038

0.070

0.129

0.000

0.871

0.129

  

Kinh in Ho Chi Minh City, Vietnam (KHV)

0.051

0.056

0.157

0.005

0.838

0.157

0.005

 

European (EUR)

European (EUR)

0.272

0.134

0.344

0.416

0.391

0.265

0.194

0.150

Utah Residents (CEPH) with Northern and Western European Ancestry (CEU)

0.298

0.187

0.364

0.485

0.333

0.303

0.182

0.182

Toscani in Italia (TSI)

0.238

0.094

0.397

0.355

0.402

0.243

0.201

0.154

Finnish in Finland (FIN)

0.207

0.126

0.232

0.455

0.414

0.354

0.131

0.101

British in England and Scotland (GBR)

0.313

0.121

0.335

0.412

0.385

0.280

0.203

0.132

Iberian Population in Spain (IBS)

0.308

0.145

0.383

0.351

0.444

0.206

0.178

0.173

South Asian (SAS)

South Asian (SAS)

0.069

0.053

0.168

0.139

0.714

0.147

0.119

0.020

Gujarati Indian from Houston, Texas (GIH)

0.092

0.049

0.146

0.155

0.723

0.131

0.121

0.024

Punjabi from Lahore, Pakistan (PJL)

0.089

0.057

0.151

0.130

0.745

0.125

0.104

0.026

Bengali from Bangladesh (BEB)

0.052

0.023

0.157

0.116

0.756

0.128

0.087

0.029

Sri Lankan Tamil from the UK (STU)

0.059

0.093

0.177

0.113

0.721

0.167

0.103

0.010

Indian Telugu from the UK (ITU)

0.049

0.039

0.206

0.177

0.632

0.191

0.162

0.015

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