Table 2 Comparison of clinicopathological features of patients with enriched ECM and low ECM gene signature using Pearson’s chi-square analysis (TCGA-KIRC dataset).

Clinical parameter	High ECM (n = 255)	Low ECM (n = 255)	Pearson χ2 p-value	Clinical parameter	High ECM (n = 255)	Low ECM (n = 255)	Pearson χ2 p-value
Age			1	Fraction genome altered			< 0.01*
< 66 years	128	128		< 0.120	108	150
> 66 years	127	127		> 0.120	147	105
Ethnicity			< 0.01*	OS			0.05
African American	36	19		< 5 years	191	171
Caucasian	213	227		> 5 years	64	84
Sex			0.51	OS status			< 0.01*
Female	89	96		Living	150	192
Male	166	159		Deceased	105	63
Stage			< 0.01*	PFS			< 0.02
I + II	132	171		< 5 years	206	185
III + IV	123	84		> 5 years	49	70
Lymph Node			0.059	PFS Status			< 0.01*
N0	117	111		No progression	153	199
N1	12	4		Progression	102	56
Metastasis			< 0.01*	DSS			0.05
No Metastasis M0	188	213		< 5 years	191	171
Metastasis M1	51	27		> 5 years	64	84
Aneuploidy score			< 0.01*	DSS status			< 0.01*
> 4	143	81		Tumor free	172	221
< 4	112	174		Dead with tumor	76	31

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