Figure 3
From: Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)
Vitamin D and lumisterol hydroxyderivatives stimulate the expression of LXR-dependent genes. (A) QPCR analysis of changes in expression of genes downstream of LXR in murine dermal fibroblasts treated with 10–7 M 1,25(OH)2D3, 20(OH)D3, 1,20(OH)2D3, 20,23(OH)2D3, 1,20,23(OH)3D3, 20(OH)7DHC, 20(OH)L3 or 20(OH)C, or ethanol (control) for 24 h. (B) Stimulation of LXR-dependent gene expression in the brain of SKH-1 (B) or Ptch+/−/SKH-1 (C) mice (n = 3 per group) treated with 20 µg/kg of 20(OH)D3, respectively, for 6 h. Data are presented as means ± SD, n = 3. Statistical analysis was done using the t-test: *p < 0.05, **p < 0.01, ***p < 0.001 or ****p < 0.0001 versus control (ethanol).
