Figure 6 | Scientific Reports

Figure 6

From: Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines

Figure 6

Evaluation of AXIN1-repaired SNU449 cells. At baseline (0 μM XAV939) the AXIN1-repaired SNU449 cells show increased levels of AXIN1, while AXIN2 and total β-catenin levels are decreased, indicating that AXIN1 contributes to increased β-catenin turnover. Following XAV939 treatment at indicated dosages, only a clear accumulation is observed for the AXIN1-repaired protein. For this experiment the AXIN1-repaired SNU449 clone-20 was compared with control clone-2. All relative band intensities are compared to this latter clone, which were arbitrarily set to 1.

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