Table 3 The results of non-compartmental pharmacokinetic analysis of the Proleukin and S2A concentration versus time data.

From: Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity

 

Proleukin 180 pmol (8000 IU)

S2A 15 pmol (3000 IU)

S2A 30 pmol (6000 IU)

S2A 60 pmol (12,000 IU)

t½ (h)

0.744 ± 0.07

14.1 ± 2.5

7.88 ± 2.8

9.3 ± 1.9

Tmax (h)

1

1.75

3.2

1.8

Cmax (pmol/ml)

0.0132 ± 0.0006

0.0031 ± 0.001

0.0047 ± 0.00135

0.0125 ± 0.001

AUC0-t (pmol/ml × h)

0.246 ± 0.0006

0.0335 ± 0.01

0.0936 ± 0.03

0.194 ± 0.019

Frel (IU fold)

1

3.64

5.08

5.27

  1. Average ± SD, n = 5. Analysis performed in PKsolver add-in to Microsoft Excel.
Back to article page