Figure 4 | Scientific Reports

Figure 4

From: Endovascular repair and open repair surgery of thoraco-abdominal aortic aneurysms cause drastically different types of spinal cord injury

Figure 4

The SC of EVR and OR dogs express different markers of cell death. (a) IHC for Parp3 (brown) on cross-sections at L3 and S3 levels in an OR dog (top left and right panels, respectively), and at L3 in EVR dog#3. Arrowheads point at motor neurons. (b) Box and whisker plots showing Gasdermin D expression assessed by IHC on multiple lumbar cross-sections of a control dog (C), an OR dog, and EVR dog #1 (E1) and dog#3 (E3). The cross gives the mean value. (c) Bright field (upper left panel) and immunofluorescence (three other panels) showing co-localization between Gasdermin D (GSDMD, green) and neurofilament heavy polypeptide (NF, red) on L5 cross-sections from EVR dog#3. Yellow: co-expression. (d) Bright field (upper panel) and immunofluorescence (lower panel) showing lack of co-localization between Gasdermin D (GSDMD, green) and S100 (oligodendroglial marker, red) on L5 cross-sections from EVR dog#3. Scale bars are in µm.

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