Figure 3

Changes in alpha and beta diversity by HIV infection status. In (A), we show that HIV infection and treatment were associated with decreases in community diversity using the Inverse Simpson, Shannon, and phylogenetic diversity (Faith’s PD) measures. (B) Plots the PCoA for the first two principal coordinates of weighted and unweighted UniFrac distances. ADONIS testing revealed differences in clustering by HIV status for both weighted and unweighted measures (p < 1e−5). Differences in bacterial composition between HIV-infected and HIV non-infected are captured in the first two principal coordinates as shown in (C).