Table 2 Correlation of common gene mutations in CRC according to the clinicopathological data of our cohort.

Mutations	T stage		N stage		M stage		Stage
Mutations	1, 2	3, 4	0	1, 2	0	1	1, 2	3, 4
RAS	p = 0.8676		p = 0.4023		p = 0.5007		p = 0.7053
Negative	6	63	14	55	42	27	11	58
Positive	5	71	21	55	41	35	15	61
BRAF	p = 1		p = 0.6752		p = 0.04222		p = 1
Negative	11	127	33	105	82	56	25	113
Positive	0	7	2	5	1	6	1	6
PIK3CA	p = 0.7073		p = 0.7166		p = 0.05119		p = 0.9012
Negative	8	105	26	87	70	43	21	92
Positive	3	29	9	23	13	19	5	27
TP53	p = 0.09612		p = 0.01803		p = 0.4125		p = 0.03813
Negative	6	39	17	28	23	22	13	32
Positive	5	95	18	82	60	40	13	87
APC^c	p = 0.7598		p = 1		p = 0.2234		p = 0.9395
Negative	4	44	10	38	30	18	9	39
Positive	7	60	15	52	33	34	11	56
SMAD4	p = 1		p = 1		p = 0.904		p = 0.5087
Negative	10	118	31	97	74	54	22	106
Positive	1	16	4	13	9	8	4	13
FBXW7	p = 0.03191		p = 0.1424		p = 0.9203		p = 0.09594
Negative	7	120	28	99	72	55	20	107
Positive	4	14	7	11	11	7	6	12
ATM	p = 0.01237		p = 0.7439		p = 1		p = 0.717
Negative	7	124	31	100	75	56	23	108
Positive	4	10	4	10	8	6	3	11

Mutations	Age		Sex		Differentiation^a		Lymphatic invasion^b		Vascular invasion^b		Perineural invasion^b
Mutations	< 60	≥ 60	M	F	W to M	Poorly	Absent	Present	Absent	Present	Absent	Present
RAS	p = 0.8369		p = 0.437		p = 0.9249		p = 0.1176		p = 0.9134		p = 0.972
Negative	33	36	39	30	56	8	17	43	37	23	32	28
Positive	34	42	37	39	60	7	29	38	43	24	37	30
BRAF	p = 0.2491		p = 0.2577		p = 0.1002		p = 1		p = 1		p = 0.3746
Negative	62	76	74	64	113	13	44	78	77	45	65	57
Positive	5	2	2	5	3	2	2	3	3	2	4	1
PIK3CA	p = 0.6054		p = 0.3622		p = 0.3053		p = 1		p = 0.8195		p = 0.7176
Negative	54	59	62	51	90	14	36	64	64	36	53	47
Positive	13	19	14	18	26	1	10	17	16	11	16	11
TP53	p = 1		p = 0.6962		p = 0.1422		p = 0.08001		p = 0.2426		p = 0.201
Negative	21	24	22	23	32	7	19	20	28	11	25	14
Positive	46	54	54	46	84	8	27	61	52	36	44	44
APC^c	p = 0.8859		p = 0.6938		p = 0.09394		p = 0.5736		p = 0.1451		p = 0.9066
Negative	23	25	27	21	37	9	16	27	29	14	22	21
Positive	30	37	34	33	55	4	17	40	29	28	31	26
SMAD4	p = 0.8541		p = 0.832		p = 0.6913		p = 0.3429		p = 1		p = 0.9175
Negative	60	68	68	60	100	14	38	73	70	41	61	50
Positive	7	10	8	9	16	1	8	8	10	6	8	8
FBXW7	p = 1		p = 0.01063		p = 1		p = 0.4667		p = 0.6693		p = 0.2363
Negative	59	68	61	66	101	13	38	72	68	42	57	53
Positive	8	10	15	3	15	2	8	9	12	5	12	5
ATM	p = 0.986		p = 0.5129		p = 0.6284		p = 0.35		p = 0.7595		p = 0.5505
Negative	60	71	67	64	106	13	40	75	73	42	61	54
Positive	7	7	9	5	10	2	6	6	7	5	8	4

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