Figure 1 | Scientific Reports

Figure 1

From: Tadalafil ameliorates bladder overactivity by restoring insulin-activated detrusor relaxation via the bladder mucosal IRS/PI3K/AKT/eNOS pathway in fructose-fed rats

Figure 1

Glucose tolerance, urinary NO content and micturition behavior of experimental animals. (A) The response curves of plasma glucose to oral glucose tolerance (OGTT) test, (B) metabolic cage study and filling cystometry, and (C) levels of urinary nitrite and nitrate (NOx) before and at 2 h after insulin stimulation in control (C) and fructose fed rats (F), alone or with addition of tadalafil (T) or metformin (M) treatment. Data are represented in mean ± SEM, n = 12 animals in each group. *p < 0.05 in comparison with the control group by one-way ANOVA with Dunnett’s test, and ✝p < 0.05 in paired t-test. Arrows indicate the non-voided contraction, and arrowhead denotes the increased basal tone in (B).

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