Table 2 Kinase inhibitors that were determined to be negative regulators of neurite formation at 10 µM and regulators of neurite initiation or elongation at all doses (0.1, 1, 10 µM).
Kinase inhibitor | Pathway | Target kinase |
|---|---|---|
Negative regulators (10 µM) | ||
SNS-032 (BMS-387032) | Cell cycle/checkpoint | Cyclin-dependent kinases |
D4476 | Stem cell | CK1 |
BX795 | PI3K/Akt/mTOR signaling | Akt |
R406 | Tyrosine kinase/adaptors | Spleen tyrosine kinase (Syk) |
GNF 5 | TGF-β / Smad signaling | Bcr-Abl |
CCT128930 | PI3K/Akt/mTOR signaling | Akt |
LEE011 | Cell cycle/checkpoint | Cyclin-dependent kinases |
Icotinib | JAK/STAT signaling | EGFR |
NSC 23766 | Cell cycle/checkpoint | Rho |
Regulators of neurite initiation (all doses) | ||
WAY-600 | PI3K/Akt/mTOR signaling | mTOR |
TCS JNK 5a | MAPK signaling | JNK |
KX2-391 | Tyrosine kinase | Src |
KX2-391 dihydrochloride | Tyrosine kinase/adaptors | Src |
Tivantinib (ARQ 197) | Tyrosine kinase/adaptors | c-MET |
Nocodazole | Ubiquitination | Autophagy |
Regulators of Neurite Elongation (all doses) | ||
PP 1 | Tyrosine kinase/adaptors | Src |
ZCL278 | Cell cycle/checkpoint | Cdc42 |
PH-797804 | MAPK signaling | p38 |
ML347 | TGF-β / smad signaling | TGF-βR1(ALK5) |
Torin 2 | PI3K/Akt/mTOR signaling | mTOR |
