Table 4 Summary table of the phenotypes observed in primary cortical neurons when each Aurora and Nuak kinase was either overexpressed or inhibited.
| Â | Length of neurites likely to become dendrites (elongation) | Length of Neurites likely to become axons (elongation) | Neurite initiation | Arborization |
|---|---|---|---|---|
Aurora A overexpression | X | X | Increased | Increased proximally, decreased distally |
Aurora A inhibition | X | X | X | Mild decrease |
Aurora B overexpression | X | X | X | Increased proximally, decreased distally |
Aurora B inhibition | Decreased | Decreased | X | Decreased |
Aurora A/B inhibition | X | X | Decreased | Decreased |
Aurora B/C inhibition | Decreased | Decreased | Decreased | Decreased |
Aurora A/B/C inhibition | Decreased | Decreased | Decreased | Decreased |
Aurora C overexpression | X | X | X | Increased proximally, decreased distally |
Nuak 1 overexpression | X | X | Increased | Increased proximally, decreased distally |
Nuak 1 inhibition | Decreased | Decreased | Decreased | Decreased |
Nuak 2 overexpression | X | X | X | Increased proximally, decreased distally |
Nuak 1/2 inhibition | Decreased | Decreased | Decreased | Decreased |
