Figure 6
From: 3D cell sheet structure augments mesenchymal stem cell cytokine production
MSC sheet 3D structural and molecular transition. A schematic representation of TRCD-cultured MSC sheet temperature detachment and sheet contraction resulting in a tissue-like 3D system. 2D–3D transition prompts dynamic cell morphology and actin cytoskeleton changes with increased cell–cell interactions. These features of 3D MSC sheet culture and production augment MSC paracrine-relevant secretory capacity. Created with BioRender.com.
