Table 2 Short and Medium Chain Fatty Acids associations with recent, persistent normoalbuminuria in subjects with a long duration of T1D and normal renal function.
Metabolite | Chemical formula | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
OR (95% CI) | Nominal p | Bonferroni p | OR (95% CI) | Nominal p | ||
Short Chain Fatty Acid (SCFA) | ||||||
Glutarate | C5H8O4 | 0.28 (0.20, 0.40) | 8.4E−13 | 3.0E−10 | 0.33 (0.21, 0.52) | 1.8E−6 |
2-hydroxyglutarate | C5H8O5 | 0.25 (0.18, 0.36) | 6.5E−14 | 2.3E−11 | 0.29 (0.18, 0.46) | 1.8E−7 |
4-hydroxycarboxylate | C4H8O3 | 0.45 (0.34, 0.60) | 3.1E−8 | 1.1E−5 | 0.50 (0.34, 0.73) | 3.3E−4 |
Medium Chain Fatty Acid (MCFA) | ||||||
Dicarboxylate | ||||||
Odd-numbered | ||||||
Nonanedioate | C9H16O4 | 0.21 (0.14, 0.31) | 1.3E−14 | 4.5E−12 | 0.23 (0.13, 0.39) | 6.4E−8 |
Undecanedioate | C11H20O4 | 0.19 (0.13, 0.30) | 1.9E−14 | 6.5E−12 | 0.18 (0.10, 0.33) | 1.5E−8 |
Even-numbered | ||||||
Hexanedioate | C6H10O4 | 0.33 (0.24, 0.46) | 8.8E−12 | 3.1E−9 | 0.36 (0.23, 0.57) | 1.2E−5 |
Octanedioate | C8H14O4 | 0.18 (0.12, 0.28) | 4.1E−15 | 1.5E−12 | 0.18 (0.10, 0.32) | 9.0E−9 |
Decanedioate | C10H18O4 | 0.16 (0.10, 0.25) | 4.2E−15 | 1.5E−12 | 0.15 (0.08, 0.29) | 1.1E−8 |
Dodecanedioate | C12H22O4 | 0.21 (0.14, 0.32) | 1.8E−14 | 6.2E−12 | 0.23 (0.14, 0.39) | 3.8E−8 |
Monocarboxylate | ||||||
Odd-numbered | ||||||
Heptanoate | C7H14O2 | 0.32 (0.23, 0.44) | 2.1E−11 | 7.3E−9 | 0.30 (0.19, 0.47) | 1.4E−7 |
Nonanoate | C9H18O2 | 0.14 (0.09, 0.23) | 7.0E−16 | 2.5E−13 | 0.14 (0.07, 0.27) | 2.7E−9 |
Undecanoate | C11H22O2 | 0.20 (0.13, 0.30) | 5.0E−15 | 1.7E−12 | 0.23 (0.13, 0.39) | 6.6E−8 |
Even-numbered | ||||||
Octanoate | C8H16O2 | 0.48 (0.37, 0.64) | 6.3E−7 | 2.2E−4 | 0.56 (0.38, 0.82) | 3.0E−3 |