Table 2 Short and Medium Chain Fatty Acids associations with recent, persistent normoalbuminuria in subjects with a long duration of T1D and normal renal function.

From: Circulating short and medium chain fatty acids are associated with normoalbuminuria in type 1 diabetes of long duration

Metabolite

Chemical formula

Model 1

Model 2

OR (95% CI)

Nominal p

Bonferroni p

OR (95% CI)

Nominal p

Short Chain Fatty Acid (SCFA)

Glutarate

C5H8O4

0.28 (0.20, 0.40)

8.4E−13

3.0E−10

0.33 (0.21, 0.52)

1.8E−6

2-hydroxyglutarate

C5H8O5

0.25 (0.18, 0.36)

6.5E−14

2.3E−11

0.29 (0.18, 0.46)

1.8E−7

4-hydroxycarboxylate

C4H8O3

0.45 (0.34, 0.60)

3.1E−8

1.1E−5

0.50 (0.34, 0.73)

3.3E−4

Medium Chain Fatty Acid (MCFA)

Dicarboxylate

 Odd-numbered

  Nonanedioate

C9H16O4

0.21 (0.14, 0.31)

1.3E−14

4.5E−12

0.23 (0.13, 0.39)

6.4E−8

  Undecanedioate

C11H20O4

0.19 (0.13, 0.30)

1.9E−14

6.5E−12

0.18 (0.10, 0.33)

1.5E−8

 Even-numbered

  Hexanedioate

C6H10O4

0.33 (0.24, 0.46)

8.8E−12

3.1E−9

0.36 (0.23, 0.57)

1.2E−5

  Octanedioate

C8H14O4

0.18 (0.12, 0.28)

4.1E−15

1.5E−12

0.18 (0.10, 0.32)

9.0E−9

  Decanedioate

C10H18O4

0.16 (0.10, 0.25)

4.2E−15

1.5E−12

0.15 (0.08, 0.29)

1.1E−8

  Dodecanedioate

C12H22O4

0.21 (0.14, 0.32)

1.8E−14

6.2E−12

0.23 (0.14, 0.39)

3.8E−8

Monocarboxylate

 Odd-numbered

  Heptanoate

C7H14O2

0.32 (0.23, 0.44)

2.1E−11

7.3E−9

0.30 (0.19, 0.47)

1.4E−7

  Nonanoate

C9H18O2

0.14 (0.09, 0.23)

7.0E−16

2.5E−13

0.14 (0.07, 0.27)

2.7E−9

  Undecanoate

C11H22O2

0.20 (0.13, 0.30)

5.0E−15

1.7E−12

0.23 (0.13, 0.39)

6.6E−8

 Even-numbered

  Octanoate

C8H16O2

0.48 (0.37, 0.64)

6.3E−7

2.2E−4

0.56 (0.38, 0.82)

3.0E−3

  1. Logistic regression analyses are adjusted for clinical covariates. Model 1 is corrected for age, gender, HbA1c, and eGFR. Model 2 is additionally corrected for systolic blood pressure, diastolic blood pressure, cholesterol, HDL, ACE inhibitor/ARB use, other antihypertensive treatment, and statin use. Effect sizes are shown per one quartile change. Protective Short and Medium Chain Fatty Acids are ordered by structural features and subsequently by the number of carbons. OR odds ratio, CI confidence intervals. For more comprehensive logistic analyses of all Fatty Acids, please refer to Supplementary Table S1.