Figure 3
Brain synaptic proteins including PSD95 (A) and synaptophysin (B) and Alzheimer’s related proteins including the ratios of Amyloid-β/APP (C) and phosphorylated-TauThr181/Tau (D) of β-thalassemic mice fed with either normal diet or high-iron diet. Three replicates of cropped representative bands for brain FGF21 signaling proteins are shown (E). In addition, full-length blots are presented in Supplementary Fig. 2. The samples derive from the same experiment and that gels/blots were processed in parallel. Actin was used as a loading control and the density of detected protein was divided by the density of actin from the sample. APP amyloid precursor protein, HFe high-iron diet fed mice, HT heterozygous-β knockout, ND normal diet fed mice, PSD95 post-synaptic density 95. *p < 0.05 vs. HT-mice fed with normal diet.
