Table 3 Binary logistic regression analysis of association to determine the factors associated with mild cognitive impairment in thalassemia patients.
Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
Odds ratio (95% CI) | p-value | Odds ratio (95% CI) | p-value | |
Age (years) | 1.049 (1.010–1.090) | 0.011 | 1.057 (1.004–1.112) | 0.034 |
Hemoglobin (g/dL) | 0.922 (0.702–1.211) | 0.558 | 1.150 (0.814–1.624) | 0.428 |
ln FGF21 | 2.107 (1.317–3.371) | 0.002 | 1.858 (1.074–3.213) | 0.027 |
ln maximum serum ferritin in 5 years | 1.806 (1.084–3.007) | 0.023 | 1.441 (0.710–2.926) | 0.312 |
Sex | ||||
Male | 1 | Reference | ||
Female | 1.127 (0.553–2.676) | 0.626 | 1.759 (0.687–4.501) | 0.239 |
Education level | ||||
Below bachelor’s degree | 1 | Reference | 1 | Reference |
Bachelor’s degree and above | 0.261 (0.117–0.580) | 0.001 | 0.282 (0.112–0.707) | 0.007 |
Thalassemia type | ||||
Alpha-thalassemia | 1 | Reference | 1 | Reference |
Beta-thalassemia | 1.123 (0.418–3.014) | 0.818 | 2.236 (0.419–11.932) | 0.346 |
Splenectomy status | ||||
Non-splenectomy | 1 | Reference | 1 | Reference |
Splenectomy | 0.817 (0.412–1.842) | 0.718 | 0.619 (0.222–1.727) | 0.360 |
Transfusion dependent status | ||||
NTDT | 1 | Reference | 1 | Reference |
TDT | 1.462 (0.685–3.122) | 0.326 | 1.187 (0.385–3.661) | 0.765 |
