Table 2 Proteins identified to be significantly different in plasma of CKD patients as compared to the healthy control group.

From: Detection of pro angiogenic and inflammatory biomarkers in patients with CKD

Target

CKD relative to healthy

Biological pathways

CKD/healthy

p value

PSP

2.4

< 0.0001

Cell proliferation and differentiation

Desmocollin 2

2.3

< 0.0001

Cell–cell junctions

Sclerostin

2.2

< 0.0001

Bone formation

Cystatin C

2.2

< 0.0001

Protein degradation

FABPL

2.1

< 0.0001

Fatty acid metabolism

REG4

2.1

< 0.0001

Cell proliferation, generation

tPA

1.9

< 0.0001

Fibrinolysis

IGFBP-6

1.9

< 0.0001

Cell proliferation, angiogenesis

CD59

1.9

< 0.0001

Complement-induced lysis, T cell activation

Ephrin-A4

1.8

< 0.0001

Angiogenesis

EFNB2

1.8

< 0.0001

Angiogenesis

SECTM1

1.8

< 0.0001

Immune response, inflammation

Ephrin-A2

1.8

< 0.0001

Angiogenesis

SMOC1

1.7

< 0.0001

Angiogenesis, fibrosis

Ephrin-A5

1.7

< 0.0001

Angiogenesis

VEGF-D

1.7

< 0.0001

Angiogenesis

PIANP

1.6

< 0.0001

Immune modulation

Endostatin

1.6

< 0.0001

Angiogenesis

MIA

1.6

< 0.0001

Cell proliferation, extracellular matrix

TIMP-1

1.5

< 0.0001

Extracellular matrix

VEGF-A

1.5

< 0.0001

Angiogenesis

NEGR-1

1.3

0.0001

Cell adhesion, axon sprouting

  1. The data are shown ratiometrically for relative fluorescence units (RFU) for CKD/healthy control. CKD: chronic kidney disease, PSP: phosphoserine phosphatase, FABPL: fatty acid-binding protein, liver-type, REG4: regenerating islet-derived protein 4, tPA: tissue plasminogen activator, IGFBP-6: insulin-like growth factor-binding protein, EFN: ephrin, SECTM1: secreted and transmembrane protein 1, Ephrin: Eph family receptor interacting proteins, SMOC1: secreted modular calcium-binding protein 1, VEGF: vascular endothelial growth factor, PIANP: PILR Alpha Associated Neural Protein, MIA: melanoma inhibitory activity, TIMP-1: tissue inhibitor of metalloproteinases, NEGR: neuronal growth regulator.
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