Table 3 Proteins identified to be significantly different for post-transplant CKD as compared to the healthy control group.

From: Detection of pro angiogenic and inflammatory biomarkers in patients with CKD

Target

Post-transplant CKD patients relative to healthy

Biological pathways

Transplant/healthy

p value

Cystatin C

1.9

< 0.0001

Protein degradation

IGFBP-6

1.9

0.0002

Cell proliferation, angiogenesis

REG4

1.8

< 0.0001

Cell proliferation, generation

CD59

1.6

< 0.0001

Complement-induced lysis, T cell activation

Ephrin-A4

1.6

0.0002

Angiogenesis

EFNB2

1.6

0.0001

Angiogenesis

SMOC1

1.5

< 0.0001

Angiogenesis, fibrosis

Ephrin-A2

1.5

< 0.0001

Angiogenesis

VEGF-D

1.5

< 0.0001

Angiogenesis

Endostatin

1.5

< 0.0001

Angiogenesis

TIMP-1

1.4

< 0.0001

Extracellular matrix

NEGR-1

1.3

< 0.0001

Cell adhesion, axonal sprouting

  1. The data are shown ratiometrically for relative fluorescence units (RFU) for CKD/healthy control. CKD: chronic kidney disease, IGFBP-6: insulin-like growth factor-binding protein, VEGF: vascular endothelial growth factor, SECTM1: secreted and transmembrane protein 1, REG4: regenerating islet-derived protein 4, Ephrin: Eph family receptor interacting proteins, EFN: ephrin. p value was considered significant < 0.0002 for individuals proteins, TIMP-1: tissue inhibitor of metalloproteinases, NEGR: neuronal growth regulator.
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