Figure 3 | Scientific Reports

Figure 3

From: The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice

Figure 3The alternative text for this image may have been generated using AI.

The effects of treatment with oxytocin receptor antagonist (OXT-A) following gestational stress, and fluoxetine treatment plus environmental enrichment (FLX + EE) on anxiety-like behavior in the open field test (A; inner zone time) and depression-like behavior in the social interaction (B; total interaction time), sucrose preference (C), and forced swim test (D; immobility time) during the postpartum period in dams. Values are presented as mean ± SEM (N = 10). Significant differences: *P < 0.05 and **P < 0.01, compared to non-stress group; + P < 0.05 and +  + P < 0.01, compared to stress group; &P < 0.05 and &&P < 0.01, compared to stress + FLX + EE + vehicle group.

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