Figure 4
From: Phenylethynylbenzyl-modified biguanides inhibit pancreatic cancer tumor growth
Effects of biguanides on mitochondrial morphology. (A) Mitochondrial morphology in KP4 cells 24 h following the indicated treatments as visualised by anti-TOMM20 immunofluorescence. Scale bar = 10 µM. (B) Quantification of the percentage of cells exhibiting filamentous, fragmented or punctuated mitochondria following indicated treatments. The data represents the mean of 2 biological replicates and for each replicate three counts of 50 cells were done. n = 300 cells per treatment. Data was analyzed with one way ANOVA followed by Tukey HSD test.
